Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research염증성 질환 치료를 위한 음파 고슴도치 경로: 향후 연구를 위한 의미 및 기회Editorial Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute myeloid leukemia Airway inflammation allergy Arthritis Asthma atopic dermatitis Autoimmune diseases Basal cell basal cell carcinoma Breast cancer Cancer cancer development cancers Cell cellular response component conserved COVID-19 Crohn's disease different diseases disease drugs dysregulation embryogenesis Factors glioma homolog Host human body immune dysregulation immune response immune system evasion implication Infection infections Inflammation Inflammation Mediators. Inflammatory Influenza inhibit investigated involved lung carcinoma malignancies mechanism medulloblastoma Mutation Pancreatic cancer pathogen pathogen-mediated pathogenic pathway progression receptor receptor inhibitor Research rheumatoid arthritis SARS-CoV-2 viruses shifting signaling pathway targets Therapeutic approach therapeutic strategy tissue homeostasis transcriptional treat Treatment tumors [DOI] 10.1136/jitc-2021-004397 PMC 바로가기 [Article Type] Editorial
Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting차가스 질병 벡터의 인구 유전체학 및 지리적 분산 : 국내 환경에 대한 조경 동인 및 가능한 적응의 증거Research Article Published on 2022-02-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adopted approach approaches Chagas disease Community directional disease disease control dispersal disperse driver Drivers Ecuador effective Elevation embryogenesis evaluated Evidence evidence of evidenced facilitate forest gene flow Genome genomic genomic region identify indicate infestation Intervention involved landscape Local loci mapped occur outlier Population population genomics provided reactive repeated Research Rhodnius Saliva Sequencing Seven SNP marker SNP markers vector vector control zone [DOI] 10.1371/journal.pgen.1010019 PMC 바로가기 [Article Type] Research Article
ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell ReprogrammingImmunology Published on 2021-07-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] aerobic fermentation alternative oxidase Anti-viral AOX approach balancing Cell condition Control Critical cycle de novo disease domain effort embryogenesis extension fermentation handling highlight homeostasis Hypothesis identify in vitro initiated lab melatonin mTOR observation Perspective plant plants profile profiles programming progression Prophylactic raised redox biology reprogramming repurposing drugs Research SARS-CoV-2 SARS-COV-2 infection selected Stress survival target gene Therapeutic strategies transcript Transcriptome tubulin variant viral infection virus [DOI] 10.3389/fimmu.2021.673692 PMC 바로가기 [Article Type] Immunology
From Plant Survival Under Severe Stress to Anti-Viral Human Defense – A Perspective That Calls for Common Efforts심한 스트레스를 받는 식물 생존에서 항바이러스 인간 방어까지 – 공동의 노력이 필요한 관점Immunology Published on 2021-06-152022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] administration aerobic fermentation alternative oxidase alternative oxidase (AOX) Anti-viral Anti-viral therapy applied approach attack Cell cells combating common complex Critical de novo develop early cell reprogramming embryogenesis explain Genes highlighting Human Hypothesis identify in vitro knowledge organism Perspective plant profile programming promote reprogramming ReprogVirus Resilience SARS-CoV-2 selected somatic embryogenesis Stress stress tolerance Support survival target gene transcript turn Viral diseases virus virus attacks virus-infected cell [DOI] 10.3389/fimmu.2021.673723 PMC 바로가기 [Article Type] Immunology
Neprilysin expression and functions in development, ageing and disease발달, 노화 및 질병에서의 네프릴리신 발현 및 기능Review Published on 2020-12-012022-08-31 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, [키워드] Ageing AICD Alzheimer's disease Alzheimer’s disease amyloid-degrading enzyme angiotensin angiotensin receptor blocker approved Aβ peptide brain development CALLA Cancer CD10 cell proliferation changes in cognitive cognitive behaviour Compound cortex COVID-19 pathogenesis diabetes disease EGCG embryogenesis endopeptidase endopeptidase 24.11 enkephalinase enzyme Epigenetic epigenetic regulation expression foetal development function functions green tea HDACs heart failure hippocampus hypertension hypoxia immune response implicated inhibitor Intensive kidney membrane-bound memory NEP inhibitors olfactory bulbs neprilysin obesity olfactory Organisms Pathogenesis pathological conditions Pathologies peptide pharmacological treatment pharmacological treatments physiological functions prenatal prenatal hypoxia Prevent Preventive medicine Prostate cancer proteolytic receptor blocker Regulation Research Sacubitril striatum striatum. substrate substrates suggested therapeutic target Treatment type-2 diabetes upregulating valsartan [DOI] 10.1016/j.mad.2020.111363 PMC 바로가기 [Article Type] Review
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article